[HTML][HTML] Exogenous recombinant human insulin-induced severe hypersensitivity reaction precipitating hyperglycemic crisis: A clinical conundrum

KU Lijesh, RD Gupta, M SenthilRaja… - Journal of Family …, 2020 - journals.lww.com
skin biopsy showing evidence of insulin hypersensitivity. He was desensitized to insulin
according to Heinzerling et al. insulin … , latex, or cresol. Subcutaneous injections compared to …

[PDF][PDF] Clinical challenges with excipients in insulin formulations and role of concentrated insulin

KD Modi, PV Gadge, P Jain, S Pawar… - Int J Basic Clin …, 2019 - academia.edu
… and meta-cresol in adequate concentration are added in insulin … Drug intolerance reaction
to insulin therapy caused by … Skin-related complications of insulin therapy: epidemiology and …

Delayed-type Hypersensitivity Reaction to Glargine and Biphasic Isophane Human Insulin in a Filipino Patient with Type 2 Diabetes Mellitus: A Practical Approach to …

CSC Tan-Lim, AS de Peralta… - Acta Medica …, 2022 - actamedicaphilippina.upm.edu.ph
… This report illustrates a case of an insulin hypersensitivity reaction successfully diagnosed …
Severe adverse cutaneous reaction to insulin due to cresol sensitivity. Contact Dermatitis 2006…

Insulin Therapy:“When Saviour Turns Hostile”

DSMVH Nagarajappaa, SOSSM Srinivasc, R Palanya - 2022 - karger.com
… Additives in insulin preparations, such as protamine, zinc, and cresol, have been shown
to … Severe adverse cutaneous reaction to insulin due to cresol sensitivity. Contact Dermatitis. …

[HTML][HTML] Insulin Therapy:“When Saviour Turns Hostile”

D Soodhana Mohan, V Hebbal Nagarajappa… - Dubai Diabetes and …, 2022 - karger.com
… She had no known drug or food sensitivities. … Additives in insulin preparations, such as
protamine, zinc, and cresol, … Because the skin lesions in our patients were caused by the injection …

Insulin, not the preservative m-cresol, instigates loss of infusion site patency over extended durations of CSII in diabetic swine

MR Swinney, AL Cox, ED Hawkins, J Xue… - Journal of …, 2021 - Elsevier
… that they either severely over-dosed m-cresol, 27 evaluated … focusing on the dermal and
subcutaneous tissues, due to their … rat insulin kit recognizes human insulin with higher sensitivity

[PDF][PDF] The natural metabolite 4-cresol improves glucose homeostasis and enhances β-cell function

F Brial, F Alzaid, K Sonomura, Y Kamatani, K Meneyrol… - Cell Reports, 2020 - cell.com
… In vivo insulin sensitivity is not affected by 4-cresol. The … 4-cresol results in enhanced
insulin secretion, insulin content, … strate that chronic administration of a non-toxic dose of 4-cresol

[HTML][HTML] Case Report: Insulin hypersensitivity in youth with type 1 diabetes

EH Alkhatib, JB Grundman, AM Adamusiak… - Frontiers in …, 2023 - frontiersin.org
severity and presentation of insulin hypersensitivity reactions along … meta-cresol, but the
localized skin reactions persisted. … Skin intradermal testing is more sensitive, but lacks specificity…

Cutaneous adverse effects of diabetes mellitus medications and medical devices: a review

PM Jedlowski, CH Te, RJ Segal, MT Fazel - American Journal of Clinical …, 2019 - Springer
cutaneous adverse effects resulting from the use of insulin, … therapy, including protamine,
zinc, and meta-cresol [39,40,41… allosteric site of the ATP-sensitive potassium channel [125]. …

[PDF][PDF] Delayed hypersensitivity reactions caused by drug excipients: a literature review

ML Caballero, S Quirce - J Investig Allergol Clin Immunol, 2020 - jiaci.org
… Contact, systemic, and irritant cutaneous reactions have been … Drug intolerance reaction
to insulin therapy caused by … hypersensitivity reaction to the meta-cresol component of insulin